This review offers a speedy, effective, and transgene-absolutely free method for generating multinucleated skeletal myotubes from iPSCs and a useful resource for further more modeling the job of skeletal muscle in amyotrophic lateral sclerosis along with other motor neuron ailments. Importance Proto

?? ????? ?????? ????? ???? ???? ???? ????? ??? ????? ??? ?? ??? ???? ???? ???? ????? ??? ?? ?? ??? ???? ??? ??? ??????. ??? ? ?? ?? ??? ?? ?? ???? ???? ?? ??? ?? ??? ???? ?? ???? ?????? ??? ?? ?? ??? ?????. ??? ????? ???? ??? ??????, ????????? ??? ???~ ?????? ???? ??? ??? ???? ???? ???? ???

#????????#????????#???????#???????#??????#??????#?????#??????#??????#????????#????????#???????? ?? ??? ??? ???? ??? ?? ??? ?? ??? ???? ??? ??? ??? ???? ? ??????. ?? ??? ????? ??? ???? ?? ??? ?????. ?? ??? ?? ???? ?? ?? ??? ?? ??? ??? ?? ????. ?????? ???????? ?? ? ???? ?? ???? ???? ??? ? ????.

??? ??? “? ????? ??? ??? ????? ?? ??? ???? ?? ?? ?? ??? ???? ???? ?? ?? ?? ???? ??? ???? ??.”?? ???. ????? ???? ?? ???? ????? ?? ????? ?????. ???????? ?? ????? ??? ??? ?? ???? ??? ?? ??? ???? ??? ???????? ?????. ???? ??????? ??? ?? ??? ?? ??? ??????.   ??? ??? ????? ??? ?? ????

??? ? ??? ? ??? ??? ??, ???? ??? ??, ??? ?? ??? ??? ?????? ???? ??? ????. ?? ??? ??? ????, ??? ??? ??? ?? ?? ??? ??????? (??? ??? ? ?? ???). ???? ???? ?? ???? ?? ???, ?? ?? ?????.   ?? ?? ??? ?????? ?? ??? ??? ?????, ????? ??? ??????? ???? ?? ??? ?? ???? ?? ??? ??? ? ? ??. ??? ???? ?????? ?